Among them, strategies utilizing stimuli‐responsive delivery systems are highly desirable to regulate glycemia with minimal patient effort and improve the quality of life for diabetic patients. 12, 13 In this review, we will focus on the different stimuli‐responsive systems for diabetic therapeutic delivery, including pH‐responsive, glucose‐responsive, and external physical trigger

The first part covers the design of stimuli-responsive drug delivery systems based on internal stimuli, namely pH and redox agents, to trigger the drug release.

It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the drug. Hydrogels are the upcoming class of biomaterials, which act as excellent drug delivery systems. These materials have important characteristic feature that they respond to various external stimuli like pH, light, temperature, magnetic field, electric field and pressure. molecular polymers and supramolecular pseudorotaxanes for stimuli-responsive drug delivery, which not only endow the delivery systems with ﬂexible and robust attributes of non-covalent interactions but also meet the urgent need of human healthcare.18–20 Drug-delivery systems immobilized with supramolecular nanovalves, emerging as a Uncontrolled cell proliferation, peculiar nutritional environment and metabolic patterns change of tumor tissues generated acidic pH, elevated temperature, overexpressed proteins/enzymes, high levels of oxidation-deoxidation environment (GSH/ROS), which could be regarded as endogenous triggers.

Stimuli responsive drug delivery

Poly (N-isopoprylacrilamide). Poloxamers. The ideal drug delivery system is the one in which the drug delivery profile is able to respond to metabolic states and/or physiological variations (Bawa et al., 2009). This kind of Traditional drug-delivery systems suffer some drawbacks, especially premature drug release and the lack of diverse stimuli responsiveness. The partnership between suitable solid support-based drug nanocarriers and supramolecular nanovalves led to a variety of gated materials containing supramolecular switches and polymers that are capable of targeted delivery and on-demand release of drugs Among them, strategies utilizing stimuli‐responsive delivery systems are highly desirable to regulate glycemia with minimal patient effort and improve the quality of life for diabetic patients.

The porous structure of NMOFs, their biocompatibility, low toxicity, and efficient permeability turn the NMOFs into ideal carriers for therapeutic applications. 2018, Inbunden.

Mar 27, 2017 stimuli into a direct material response, for example thermo-responsive shape change in polymer gels or light-triggered drug release from

KEYWORDS diabetes, drug delivery, insulin, stimuli-responsive 1 | INTRODUCTION MSN Nanocarriers for Stimuli-Responsive Drug Delivery One of the most heavily investigated inorganic nanocarriers are those based on porous silica materials. The advent of porous silica has marked a thriving advance-ment of drug delivery for cancer treatment since their ﬁrst debut in 1952; however, International Journal of Molecular Sciences Review Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery Soﬁa Municoy 1, María I. Álvarez Echazú 1, Pablo E. Antezana 1, Juan M stimuli responsive polymer integrated targeted nanomedicine is designed for combined cancer-targeted therapy and multimodal imaging using a facile preparation method. The nanoprobes used were found to offer dual pH and temperature responsive drug delivery capability, and are specifically targeted to cancer cells which also shows intracellular MR based diagnostic and tracking ability.

with hydrogels to form a hybrid biomaterial system for controlled drug delivery. (1) passively controlled drug release, (2) stimuli-responsive drug delivery,

Drug delivery vesicles can aid in this 2. Triggered drug delivery using vesicles. Stimuli-responsive systems can roughly be Various advantages of hydrogels as drug delivery system come from their good transport properties, ability to protect drugs, proteins and peptides from the environment, bio- degradability and can be modified according to the route Stimuli-responsive hydrogels for intratumoral drug delivery. Ana C Marques UCIBIO, REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. 2021-03-16 · Covalent organic frameworks (COFs) have received much attention in the biomedical area.

• Injectable hydrogels are minimally invasive and promote drug retention in tumors. • Hydrogels may undergo phase transition or structural change in response to stimuli. • Stimuli are exogenous (light) or endogenous triggers in the tumor microenvironment. 2019-01-01 · Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes 1. Introduction.
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The polymer Stimuli-responsive Drug Delivery Systems: Volume 1: Singh, Amit (AllExcel Inc., USA), Amiji, Mansoor M (Northeastern University, USA): Amazon.se: Books. Pris: 1819 kr.

responsive [1]. Drug treatment of depression in frail eld- erly nursing home triciteten, nämligen kortvariga fyrkantsvågor (brief pulse stimulus technique dopamine release in the caudate nucleus. J Neurosci laxis in previously responsive bipolar patients: non-steroidal anti-inflammatory drugs such as aspirin and ibuprofen (46), our tired brains over-responsive to food stimuli (62, 63), making us eat more. Trans-mucosal delivery systems such as bio-adhesive gel strips with pathophysiological features for disease-responsive drug delivery and på sjukdomstillstånd-associerade stimuli ( t.ex.
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stimuli responsive polymer integrated targeted nanomedicine is designed for combined cancer-targeted therapy and multimodal imaging using a facile preparation method. The nanoprobes used were found to offer dual pH and temperature responsive drug delivery capability, and are specifically targeted to cancer cells which also shows intracellular MR based diagnostic and tracking ability.

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This review mainly focuses on nanomaterials responsive to the external stimuli used in drug-delivery systems. To overcome the drawbacks of conventional therapeutics to a tumor, the dual- and multi-responsive behaviors of nanoparticles have been harnessed to improve efficiency from a drug delivery …

Stimuli Responsive Drug Delivery Systems: From Introduction to Application [Elektronisk resurs]. Bajpai, Anil (författare). Publicerad: Smithers Rapra, 2010 Pris: 2006 kr. inbunden, 2018.

Stimuli-responsive drug delivery systems (DDS) appear as a promising approach to control and target drug delivery. When these DDS are administered, the drug release is activated and then modulated through some action or external input and facilitated by the energy supplied externally.

The nanocarriers could accumulate and penetrate tumors, and target cancer cells for achieving different applications and functions by responding to the external and internal stimuli. (Click on the image to enlarge.) Stimuli-responsive liposomes for drug delivery The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of the active pharmaceutical ingredient (API) by releasing them at a specific site of action. Biological stimuli responsive drug carriers based on keratin for triggerable drug delivery 2013-10-23 · Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Interest in stimuli-responsive polymers is steadily gaining increasing momentum especially in the ﬁelds of controlled and self-regulated drug delivery.

indistinguishable from idiopathic, L-dopa-responsive Parkinson's disease.